Différences entre les versions de « Systèmes supramoléculaires B01 »

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;'''Participants''': Nicolas Giuseppone, Mario Ruben, Mihail Stadler, Franck Hoonakker, Emilie Moulin, Jean-Marc Planeix, Mourad Elhabiri, (Ali Trabolsi)
 
;'''Participants''': Nicolas Giuseppone, Mario Ruben, Mihail Stadler, Franck Hoonakker, Emilie Moulin, Jean-Marc Planeix, Mourad Elhabiri, (Ali Trabolsi)
  
===1. How to design supramolecular systems able to generate complexity===
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==1. How to design supramolecular systems able to generate complexity==
  
  
==Specificity of interactions and integrations==
+
===Specificity of interactions and integrations===
 
# From bimolecular recognition (host-guest) to large self-assemblies
 
# From bimolecular recognition (host-guest) to large self-assemblies
 
# Hierarchy of self-assemblies
 
# Hierarchy of self-assemblies
  
  
==Dynamics is important and can take place at the three levels M, I, and I in time and space==
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===Dynamics is important and can take place at the three levels M, I, and I in time and space===
 
# Conformational Dynamic
 
# Conformational Dynamic
 
# Constitutional dynamic: reversibility of the structure of the systems components
 
# Constitutional dynamic: reversibility of the structure of the systems components
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==Reversibility is an important requirement for evolvability==
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===Reversibility is an important requirement for evolvability===
 
# Creates stocastic behavior for exploration of phenotypes
 
# Creates stocastic behavior for exploration of phenotypes
 
# Generate adaptativity by "mutations" which are driven by internal, or environmental parameters (e.g. stimuli, effectors)
 
# Generate adaptativity by "mutations" which are driven by internal, or environmental parameters (e.g. stimuli, effectors)
  
  
==Cooperativity is part of the integration processes which is important for modulations==
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===Cooperativity is part of the integration processes which is important for modulations===
 
# Allosteric effects
 
# Allosteric effects
 
# Long range interactions and colective behaviors (e.g. phase transitions)
 
# Long range interactions and colective behaviors (e.g. phase transitions)
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===2. What are the emerging properties of complex supramolecular systems===
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==2. What are the emerging properties of complex supramolecular systems==
  
==Diversity==
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===Diversity===
==Selection==
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===Selection===
==Evolution==
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===Evolution===
==New functions==
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===New functions===
==Open questions==
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===Open questions===
  
 
# Is supramolecular complexity (one of the) the support to produce thinking matter?
 
# Is supramolecular complexity (one of the) the support to produce thinking matter?
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===3. What are the applications and societal implications of complex supramolecular systems===
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==3. What are the applications and societal implications of complex supramolecular systems==
  
==Medicine==
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===Medicine===
 
# Drugs
 
# Drugs
 
# Transfections - Delivery
 
# Transfections - Delivery
 
# Imaging
 
# Imaging
  
==Celullar biology==
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===Celullar biology===
 
# Understanding of the construction of molecular networks
 
# Understanding of the construction of molecular networks
 
# Understanding protein foldings
 
# Understanding protein foldings
 
# Biomimetic behaviors
 
# Biomimetic behaviors
  
==Environmental sciences==
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===Environmental sciences===
 
# CO2 capture
 
# CO2 capture
 
# Water purification
 
# Water purification
  
==Chemistry and materials==
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===Chemistry and materials===
 
# Catalysis
 
# Catalysis
 
# Organic electronics
 
# Organic electronics
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===4. Teaching complex systems in chemistry (Strasbourg Erasmus Mundus)===
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==4. Teaching complex systems in chemistry (Strasbourg Erasmus Mundus)==
  
  

Version du 19 janvier 2012 à 17:05

Pour modifier la page : login : f1 passwd : cnsc1

Texte introductif

C = M*I*I

M: Multiplicity

  1. One single molecule can present several properties e.g. Multiplicity of binding sites, number of energy levels....
  2. Mutiplicity of components: number of components (molecular) /constituents (supramolecular) in the system

I: Interaction

  1. Complentaries of shapes, of charges, of energy levels (Program writing / reading)
  2. Thermodynamic and kinetic of the interaction (reversibility, lability), covalent / non-covalent bonds, short-range/long-range
  3. Interactions of molecules with their environments (possibly in flux of energies far from equilibrium)

I: Integration

  1. Collective structuring
  2. In space: From sub-nano, to meso, to macro
  3. In time: Modulation of structures, oscillations
  4. Emergence of new properties because of the network topologies (feedback loops)
  5. Emergence of new functions


Keywords
Dynamic systems, Adaptive behaviour, Molecular evolution, Smart functional systems, Information-gaining systems


Grand challenges
  1. Designing supramolecular systems able to generate complexity
  2. Reaching emergent properties in complex supramolecular systems
  3. Producing applications from complex supramolecular systems – societal implications
  4. Teaching complex systems in chemistry (Strasbourg Erasmus Mundus)


Participants
Nicolas Giuseppone, Mario Ruben, Mihail Stadler, Franck Hoonakker, Emilie Moulin, Jean-Marc Planeix, Mourad Elhabiri, (Ali Trabolsi)

1. How to design supramolecular systems able to generate complexity

Specificity of interactions and integrations

  1. From bimolecular recognition (host-guest) to large self-assemblies
  2. Hierarchy of self-assemblies


Dynamics is important and can take place at the three levels M, I, and I in time and space

  1. Conformational Dynamic
  2. Constitutional dynamic: reversibility of the structure of the systems components
  3. Network dynamics in coupled reactions
  4. Reversible dynamics at the three levels allow adaptation


Reversibility is an important requirement for evolvability

  1. Creates stocastic behavior for exploration of phenotypes
  2. Generate adaptativity by "mutations" which are driven by internal, or environmental parameters (e.g. stimuli, effectors)


Cooperativity is part of the integration processes which is important for modulations

  1. Allosteric effects
  2. Long range interactions and colective behaviors (e.g. phase transitions)
  3. Auto-catalysis and cross-catalysis
  4. Cooperativity allows emergence


2. What are the emerging properties of complex supramolecular systems

Diversity

Selection

Evolution

New functions

Open questions

  1. Is supramolecular complexity (one of the) the support to produce thinking matter?
  2. If yes, is this pathway continuous or does it present at one point a strong nonlinearity in evolution? Information/consciousness?


3. What are the applications and societal implications of complex supramolecular systems

Medicine

  1. Drugs
  2. Transfections - Delivery
  3. Imaging

Celullar biology

  1. Understanding of the construction of molecular networks
  2. Understanding protein foldings
  3. Biomimetic behaviors

Environmental sciences

  1. CO2 capture
  2. Water purification

Chemistry and materials

  1. Catalysis
  2. Organic electronics
  3. Solar cells
  4. Self-healing materials
  5. Smart materials (responsive/adaptive)
  6. Molecular motors
  7. Information processing and engineering


4. Teaching complex systems in chemistry (Strasbourg Erasmus Mundus)

Object (ceci est un exemple, à adapter pour l'objet du groupe de travail)
F1 - Reconstructing the multi scale dynamics of multi cellular
F1 - Physiological functions
F1 - Ecosystemic complexity
F1 - From individual cognition to social cognition
F1 - Innovation, learning and co-evolution
F1 - Territorial intelligence and sustainable development
F1 - Ubiquitous Computing
Questions
F1 - Perturbations and robustness of complex systems
F1 - From optimal control to multi-scale governance
F1 - Reconstruction of multi-scale dynamics and emergence and immergence processes
F1 - Designing Artificial Complex Systems
F1 - Emergence: collective behavior and fluctuations out-of-equilibrium

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