Différences entre les versions de « Systèmes supramoléculaires B01 »
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− | Participants : ?? | + | ;'''Participants''': Nicolas Giuseppone, Mario Ruben, Mihail Stadler, Franck Hoonakker, Emilie Moulin, Jean-Marc Planeix, Mourad Elhabiri, (Ali Trabolsi) |
+ | |||
+ | ===1. How to design supramolecular systems able to generate complexity=== | ||
+ | |||
+ | |||
+ | ==Specificity of interactions and integrations== | ||
+ | # From bimolecular recognition (host-guest) to large self-assemblies | ||
+ | # Hierarchy of self-assemblies | ||
+ | |||
+ | |||
+ | ==Dynamics is important and can take place at the three levels M, I, and I in time and space== | ||
+ | # Conformational Dynamic | ||
+ | # Constitutional dynamic: reversibility of the structure of the systems components | ||
+ | # Network dynamics in coupled reactions | ||
+ | # Reversible dynamics at the three levels allow adaptation | ||
+ | |||
+ | |||
+ | ==Reversibility is an important requirement for evolvability== | ||
+ | # Creates stocastic behavior for exploration of phenotypes | ||
+ | # Generate adaptativity by "mutations" which are driven by internal, or environmental parameters (e.g. stimuli, effectors) | ||
+ | |||
+ | |||
+ | ==Cooperativity is part of the integration processes which is important for modulations== | ||
+ | # Allosteric effects | ||
+ | # Long range interactions and colective behaviors (e.g. phase transitions) | ||
+ | # Auto-catalysis and cross-catalysis | ||
+ | # Cooperativity allows emergence | ||
+ | |||
+ | |||
+ | ===2. What are the emerging properties of complex supramolecular systems=== | ||
+ | |||
+ | ==Diversity== | ||
+ | ==Selection== | ||
+ | ==Evolution== | ||
+ | ==New functions== | ||
+ | ==Open questions== | ||
+ | |||
+ | # Is supramolecular complexity (one of the) the support to produce thinking matter? | ||
+ | # If yes, is this pathway continuous or does it present at one point a strong nonlinearity in evolution? Information/consciousness? | ||
+ | |||
+ | |||
+ | ===3. What are the applications and societal implications of complex supramolecular systems=== | ||
+ | |||
+ | ==Medicine== | ||
+ | # Drugs | ||
+ | # Transfections - Delivery | ||
+ | # Imaging | ||
+ | |||
+ | ==Celullar biology== | ||
+ | # Understanding of the construction of molecular networks | ||
+ | # Understanding protein foldings | ||
+ | # Biomimetic behaviors | ||
+ | |||
+ | ==Environmental sciences== | ||
+ | # CO2 capture | ||
+ | # Water purification | ||
+ | |||
+ | ==Chemistry and materials== | ||
+ | # Catalysis | ||
+ | # Organic electronics | ||
+ | # Solar cells | ||
+ | # Self-healing materials | ||
+ | # Smart materials (responsive/adaptive) | ||
+ | # Molecular motors | ||
+ | # Information processing and engineering | ||
+ | |||
+ | |||
+ | ===4. Teaching complex systems in chemistry (Strasbourg Erasmus Mundus)=== | ||
+ | |||
+ | |||
+ | |||
+ | |||
; Object (ceci est un exemple, à adapter pour l'objet du groupe de travail) | ; Object (ceci est un exemple, à adapter pour l'objet du groupe de travail) |
Version du 19 janvier 2012 à 17:03
Pour modifier la page : login : f1 passwd : cnsc1
- Texte introductif
C = M*I*I
M: Multiplicity
- One single molecule can present several properties e.g. Multiplicity of binding sites, number of energy levels....
- Mutiplicity of components: number of components (molecular) /constituents (supramolecular) in the system
I: Interaction
- Complentaries of shapes, of charges, of energy levels (Program writing / reading)
- Thermodynamic and kinetic of the interaction (reversibility, lability), covalent / non-covalent bonds, short-range/long-range
- Interactions of molecules with their environments (possibly in flux of energies far from equilibrium)
I: Integration
- Collective structuring
- In space: From sub-nano, to meso, to macro
- In time: Modulation of structures, oscillations
- Emergence of new properties because of the network topologies (feedback loops)
- Emergence of new functions
- Keywords
- Dynamic systems, Adaptive behaviour, Molecular evolution, Smart functional systems, Information-gaining systems
- Grand challenges
- Designing supramolecular systems able to generate complexity
- Reaching emergent properties in complex supramolecular systems
- Producing applications from complex supramolecular systems – societal implications
- Teaching complex systems in chemistry (Strasbourg Erasmus Mundus)
- Participants
- Nicolas Giuseppone, Mario Ruben, Mihail Stadler, Franck Hoonakker, Emilie Moulin, Jean-Marc Planeix, Mourad Elhabiri, (Ali Trabolsi)
1. How to design supramolecular systems able to generate complexity
Specificity of interactions and integrations
- From bimolecular recognition (host-guest) to large self-assemblies
- Hierarchy of self-assemblies
Dynamics is important and can take place at the three levels M, I, and I in time and space
- Conformational Dynamic
- Constitutional dynamic: reversibility of the structure of the systems components
- Network dynamics in coupled reactions
- Reversible dynamics at the three levels allow adaptation
Reversibility is an important requirement for evolvability
- Creates stocastic behavior for exploration of phenotypes
- Generate adaptativity by "mutations" which are driven by internal, or environmental parameters (e.g. stimuli, effectors)
Cooperativity is part of the integration processes which is important for modulations
- Allosteric effects
- Long range interactions and colective behaviors (e.g. phase transitions)
- Auto-catalysis and cross-catalysis
- Cooperativity allows emergence
2. What are the emerging properties of complex supramolecular systems
Diversity
Selection
Evolution
New functions
Open questions
- Is supramolecular complexity (one of the) the support to produce thinking matter?
- If yes, is this pathway continuous or does it present at one point a strong nonlinearity in evolution? Information/consciousness?
3. What are the applications and societal implications of complex supramolecular systems
Medicine
- Drugs
- Transfections - Delivery
- Imaging
Celullar biology
- Understanding of the construction of molecular networks
- Understanding protein foldings
- Biomimetic behaviors
Environmental sciences
- CO2 capture
- Water purification
Chemistry and materials
- Catalysis
- Organic electronics
- Solar cells
- Self-healing materials
- Smart materials (responsive/adaptive)
- Molecular motors
- Information processing and engineering
4. Teaching complex systems in chemistry (Strasbourg Erasmus Mundus)
- Object (ceci est un exemple, à adapter pour l'objet du groupe de travail)
- F1 - Reconstructing the multi scale dynamics of multi cellular
- F1 - Physiological functions
- F1 - Ecosystemic complexity
- F1 - From individual cognition to social cognition
- F1 - Innovation, learning and co-evolution
- F1 - Territorial intelligence and sustainable development
- F1 - Ubiquitous Computing
- Questions
- F1 - Perturbations and robustness of complex systems
- F1 - From optimal control to multi-scale governance
- F1 - Reconstruction of multi-scale dynamics and emergence and immergence processes
- F1 - Designing Artificial Complex Systems
- F1 - Emergence: collective behavior and fluctuations out-of-equilibrium