Protein Networks
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Advances in genomics technologies and the availability of very large, diverse datasets have led to the recent study of complex biological systems, focusing on the study of genes, proteins, metabolites and molecular networks in the larger context of the cell or organism. Systems biology aims to explore the biological properties resulting from the interactions of the individual components, investigating processes at different scales and their overall systemic integration. At the highest level, pathology and physiology are determined by these interactions between many processes at different scales.
We are particularly interested in the applications of such approaches to understand the phenotypic effects of perturbations in the networks (genetic, pathogenic, environmental) and to define at which level effective intervention strategies can be developed.
Participants : Julie Thompson, Elisabeth Davioud-Charvet
- Object
- F3 - Mutation of DNA and effect on gene products
- F3 - Protein networks, metabolic pathways, flux control analysis
- F3 - Phenotypic effects
- F3 - Physio-pathologies
- F3 - Interaction host-pathogens
- F3 - Mimetism of genetic mutations by low-weight compounds
- F3 - Environmental Factors
- F3 - Enzymology
- F3 - Pharmacology
- F3 - Medicinal Chemistry
- Questions
- F1 - Perturbations and robustness of complex systems
- F1 - Multi-scale analysis and modelling from molecules to populations
- F1 - Comparison of complex systems: 'similarity'/'distance' measures
- F1 - Modelling of noisy systems: intrinsic, experimental error
- F1 - Reconstruction of multi-scale dynamics
- F1 - Emergence and immergence processes
- F1 - Deterministic versus random factors
- F1 - Designing Artificial Complex Systems: "synthetic biology"