F1 - Supramolecular Systems
Rédacteurs: Nicolas Giuseppone, Mario Ruben, Mihail Stadler, Franck Hoonakker, Emilie Moulin, Jean-Marc Planeix, Mourad Elhabiri, (Ali Trabolsi)
- Definition of complexity
- C = MxIxI
M: Multiplicity; A/ One single molecule can present several properties e.g. Multiplicity of binding sites, number of energy levels.... B/ Mutiplicity of components: number of components (molecular) /constituents (supramolecular) in the system
I: Interaction A/ Complentaries of shapes, of charges, of energy levels (Program writing / reading) B/ Thermodynamic and kinetic of the interaction (reversibility, lability), covalent / non-covalent bonds, short-range/long-range C/ Interactions of molecules with their environments (possibly in flux of energies far from equilibrium)
I: Integration A/ Collective structuring B/ In space: From sub-nano, to meso, to macro C/ In time: Modulation of structures, oscillations D/ Emergence of new properties because of the network topologies (feedback loops) E/ Emergence of new functions
- Characteristics for supramolecular complexity
- Specificity of interactions and integrations
A/ From bimolecular recognition (host-guest) to large self-assemblies B/ Hierarchy of self-assemblies
- Dynamics is important and can take place at the three levels M, I, and I.
In time and space A/ Conformational Dynamic B/ Constitutional dynamic: reversibility of the structure of the systems components C/ Network dynamics in coupled reactions D/ Reversible dynamics at the three levels allow adaptation
- Reversibility is an important requirement for evolvability
A/ Creates stocastic behavior for exploration of phenotypes B/ Generate adaptativity by "mutations" which are driven by internal, or environmental parameters (e.g. stimuli, effectors)
- Cooperativity is part of the integration processes which is important for modulations
A/ Allosteric effects B/ Long range interactions and colective behaviors (e.g. phase transitions) C/ Auto-catalysis and cross-catalysis D/ Cooperativity allows emergence
- Consequences of supramolecular complexity
- Diversity
- Selection
- Evolution
- New functions
- Open questions
A/ Is supramolecular complexity (one of the) the support to produce thinking matter? B/ If yes, is this pathway continuous or does it present at one point a strong nonlinearity in evolution? Information/consciousness?
- Possible Applications and societal implications
- Medicine
A/Drugs B/Transfections - Delivery C/Imaging
- Celullar biology
A/Understanding of the construction of molecular networks B/Understanding protein foldings C/Biomimetic behaviors
- Environmental sciences
A/CO2 capture B/Water purification
- Chemistry and materials
A/Catalysis B/Organic electronics C/Solar cells D/Self-healing materials E/Smart materials (responsive/adaptive) F/Information processing and engineering
- Teaching complex systems in chemistry (Strasbourg Erasmus Mundus)