Différences entre les versions de « F1 - Supramolecular Systems »

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Rédacteurs: Nicolas Giuseppone, Mario Ruben, Mihail Stadler, Franck Hoonakker, Emilie Moulin, Jean-Marc Planeix, Mourad Elhabiri, (Ali Trabolsi)
 
  
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===Definition of complexity===
 
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'''C = M*I*I'''
 
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==M: Multiplicity==
 
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# One single molecule can present several properties e.g. Multiplicity of binding sites, number of energy levels....
 
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# Mutiplicity of components: number of components (molecular) /constituents (supramolecular) in the system
 
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==I: Interaction==
 
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# Complentaries of shapes, of charges, of energy levels (Program writing / reading)
 
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# Thermodynamic and kinetic of the interaction (reversibility, lability), covalent / non-covalent bonds, short-range/long-range
 
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C/ Interactions of molecules with their environments (possibly in flux of energies far from equilibrium)
 
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==I: Integration==
 
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# Collective structuring
 
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# In space: From sub-nano, to meso, to macro
 
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# In time: Modulation of structures, oscillations
 
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# Emergence of new properties because of the network topologies (feedback loops)
 
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# Emergence of new functions
 
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===Characteristics for supramolecular complexity===
 
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==Specificity of interactions and integrations==
 
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# From bimolecular recognition (host-guest) to large self-assemblies
 
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# Hierarchy of self-assemblies
 
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==Dynamics is important and can take place at the three levels M, I, and I in time and space==
 
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# Conformational Dynamic
 
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# Constitutional dynamic: reversibility of the structure of the systems components
 
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# Network dynamics in coupled reactions
 
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# Reversible dynamics at the three levels allow adaptation
 
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==Reversibility is an important requirement for evolvability==
 
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# Creates stocastic behavior for exploration of phenotypes
 
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# Generate adaptativity by "mutations" which are driven by internal, or environmental parameters (e.g. stimuli, effectors)
 
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==Cooperativity is part of the integration processes which is important for modulations==
 
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# Allosteric effects
 
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# Long range interactions and colective behaviors (e.g. phase transitions)
 
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# Auto-catalysis and cross-catalysis
 
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# Cooperativity allows emergence
 
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===Consequences of supramolecular complexity===
 
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==Diversity==
 
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==Selection==
 
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==Evolution==
 
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==New functions==
 
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==Open questions==
 
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# Is supramolecular complexity (one of the) the support to produce thinking matter?
 
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# If yes, is this pathway continuous or does it present at one point a strong nonlinearity in evolution? Information/consciousness?
 
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===Possible Applications and societal implications===
 
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==Medicine==
 
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# Drugs
 
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# Transfections - Delivery
 
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# Imaging
 
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==Celullar biology==
 
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# Understanding of the construction of molecular networks
 
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# Understanding protein foldings
 
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# Biomimetic behaviors
 
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==Environmental sciences==
 
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# CO2 capture
 
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# Water purification
 
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==Chemistry and materials==
 
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# Catalysis
 
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# Organic electronics
 
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# Solar cells
 
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# Self-healing materials
 
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# Smart materials (responsive/adaptive)
 
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# Molecular motors
 
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# Information processing and engineering
 
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===Teaching complex systems in chemistry (Strasbourg Erasmus Mundus)===
 

Version actuelle datée du 19 janvier 2012 à 17:32

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