Différences entre les versions de « F1 - Supramolecular Systems »
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Ligne 1 : | Ligne 1 : | ||
Rédacteurs: Nicolas Giuseppone, Mario Ruben, Mihail Stadler, Franck Hoonakker, Emilie Moulin, Jean-Marc Planeix, Mourad Elhabiri, (Ali Trabolsi) | Rédacteurs: Nicolas Giuseppone, Mario Ruben, Mihail Stadler, Franck Hoonakker, Emilie Moulin, Jean-Marc Planeix, Mourad Elhabiri, (Ali Trabolsi) | ||
− | + | ===Definition of complexity=== | |
:C = MxIxI | :C = MxIxI | ||
− | M: Multiplicity | + | ==M: Multiplicity== |
# One single molecule can present several properties e.g. Multiplicity of binding sites, number of energy levels.... | # One single molecule can present several properties e.g. Multiplicity of binding sites, number of energy levels.... | ||
# Mutiplicity of components: number of components (molecular) /constituents (supramolecular) in the system | # Mutiplicity of components: number of components (molecular) /constituents (supramolecular) in the system | ||
− | I: Interaction | + | ==I: Interaction== |
# Complentaries of shapes, of charges, of energy levels (Program writing / reading) | # Complentaries of shapes, of charges, of energy levels (Program writing / reading) | ||
# Thermodynamic and kinetic of the interaction (reversibility, lability), covalent / non-covalent bonds, short-range/long-range | # Thermodynamic and kinetic of the interaction (reversibility, lability), covalent / non-covalent bonds, short-range/long-range | ||
C/ Interactions of molecules with their environments (possibly in flux of energies far from equilibrium) | C/ Interactions of molecules with their environments (possibly in flux of energies far from equilibrium) | ||
− | I: Integration | + | ==I: Integration== |
# Collective structuring | # Collective structuring | ||
# In space: From sub-nano, to meso, to macro | # In space: From sub-nano, to meso, to macro | ||
Ligne 22 : | Ligne 22 : | ||
− | + | ===Characteristics for supramolecular complexity=== | |
− | + | ==Specificity of interactions and integrations== | |
# From bimolecular recognition (host-guest) to large self-assemblies | # From bimolecular recognition (host-guest) to large self-assemblies | ||
# Hierarchy of self-assemblies | # Hierarchy of self-assemblies | ||
− | + | ==Dynamics is important and can take place at the three levels M, I, and I. | |
− | In time and space | + | In time and space== |
# Conformational Dynamic | # Conformational Dynamic | ||
# Constitutional dynamic: reversibility of the structure of the systems components | # Constitutional dynamic: reversibility of the structure of the systems components | ||
Ligne 35 : | Ligne 35 : | ||
# Reversible dynamics at the three levels allow adaptation | # Reversible dynamics at the three levels allow adaptation | ||
− | + | ==Reversibility is an important requirement for evolvability== | |
# Creates stocastic behavior for exploration of phenotypes | # Creates stocastic behavior for exploration of phenotypes | ||
# Generate adaptativity by "mutations" which are driven by internal, or environmental parameters (e.g. stimuli, effectors) | # Generate adaptativity by "mutations" which are driven by internal, or environmental parameters (e.g. stimuli, effectors) | ||
− | + | ==Cooperativity is part of the integration processes which is important for modulations== | |
# Allosteric effects | # Allosteric effects | ||
# Long range interactions and colective behaviors (e.g. phase transitions) | # Long range interactions and colective behaviors (e.g. phase transitions) | ||
Ligne 46 : | Ligne 46 : | ||
− | + | ===Consequences of supramolecular complexity=== | |
− | + | ==Diversity== | |
− | + | ==Selection== | |
− | + | ==Evolution== | |
− | + | ==New functions== | |
− | + | ==Open questions== | |
# Is supramolecular complexity (one of the) the support to produce thinking matter? | # Is supramolecular complexity (one of the) the support to produce thinking matter? | ||
# If yes, is this pathway continuous or does it present at one point a strong nonlinearity in evolution? Information/consciousness? | # If yes, is this pathway continuous or does it present at one point a strong nonlinearity in evolution? Information/consciousness? | ||
− | + | ===Possible Applications and societal implications=== | |
− | + | ==Medicine== | |
# Drugs | # Drugs | ||
# Transfections - Delivery | # Transfections - Delivery | ||
# Imaging | # Imaging | ||
− | + | ||
+ | ==Celullar biology== | ||
# Understanding of the construction of molecular networks | # Understanding of the construction of molecular networks | ||
# Understanding protein foldings | # Understanding protein foldings | ||
# Biomimetic behaviors | # Biomimetic behaviors | ||
− | + | ||
+ | ==Environmental sciences== | ||
# CO2 capture | # CO2 capture | ||
# Water purification | # Water purification | ||
− | + | ||
+ | ==Chemistry and materials== | ||
# Catalysis | # Catalysis | ||
# Organic electronics | # Organic electronics | ||
Ligne 76 : | Ligne 79 : | ||
# Information processing and engineering | # Information processing and engineering | ||
− | + | ===Teaching complex systems in chemistry (Strasbourg Erasmus Mundus)=== |
Version du 19 janvier 2012 à 15:44
Rédacteurs: Nicolas Giuseppone, Mario Ruben, Mihail Stadler, Franck Hoonakker, Emilie Moulin, Jean-Marc Planeix, Mourad Elhabiri, (Ali Trabolsi)
Definition of complexity
- C = MxIxI
M: Multiplicity
- One single molecule can present several properties e.g. Multiplicity of binding sites, number of energy levels....
- Mutiplicity of components: number of components (molecular) /constituents (supramolecular) in the system
I: Interaction
- Complentaries of shapes, of charges, of energy levels (Program writing / reading)
- Thermodynamic and kinetic of the interaction (reversibility, lability), covalent / non-covalent bonds, short-range/long-range
C/ Interactions of molecules with their environments (possibly in flux of energies far from equilibrium)
I: Integration
- Collective structuring
- In space: From sub-nano, to meso, to macro
- In time: Modulation of structures, oscillations
- Emergence of new properties because of the network topologies (feedback loops)
- Emergence of new functions
Characteristics for supramolecular complexity
Specificity of interactions and integrations
- From bimolecular recognition (host-guest) to large self-assemblies
- Hierarchy of self-assemblies
==Dynamics is important and can take place at the three levels M, I, and I. In time and space==
- Conformational Dynamic
- Constitutional dynamic: reversibility of the structure of the systems components
- Network dynamics in coupled reactions
- Reversible dynamics at the three levels allow adaptation
Reversibility is an important requirement for evolvability
- Creates stocastic behavior for exploration of phenotypes
- Generate adaptativity by "mutations" which are driven by internal, or environmental parameters (e.g. stimuli, effectors)
Cooperativity is part of the integration processes which is important for modulations
- Allosteric effects
- Long range interactions and colective behaviors (e.g. phase transitions)
- Auto-catalysis and cross-catalysis
- Cooperativity allows emergence
Consequences of supramolecular complexity
Diversity
Selection
Evolution
New functions
Open questions
- Is supramolecular complexity (one of the) the support to produce thinking matter?
- If yes, is this pathway continuous or does it present at one point a strong nonlinearity in evolution? Information/consciousness?
Possible Applications and societal implications
Medicine
- Drugs
- Transfections - Delivery
- Imaging
Celullar biology
- Understanding of the construction of molecular networks
- Understanding protein foldings
- Biomimetic behaviors
Environmental sciences
- CO2 capture
- Water purification
Chemistry and materials
- Catalysis
- Organic electronics
- Solar cells
- Self-healing materials
- Smart materials (responsive/adaptive)
- Information processing and engineering