Différences entre les versions de « F1 - Supramolecular Systems »
| Ligne 1 : | Ligne 1 : | ||
Rédacteurs: Nicolas Giuseppone, Mario Ruben, Mihail Stadler, Franck Hoonakker, Emilie Moulin, Jean-Marc Planeix, Mourad Elhabiri, (Ali Trabolsi) | Rédacteurs: Nicolas Giuseppone, Mario Ruben, Mihail Stadler, Franck Hoonakker, Emilie Moulin, Jean-Marc Planeix, Mourad Elhabiri, (Ali Trabolsi) | ||
| + | |||
| + | Definition of complexity | ||
C = MxIxI | C = MxIxI | ||
| Ligne 8 : | Ligne 10 : | ||
I: Interaction | I: Interaction | ||
| − | A/ Complentaries of shapes, of charges, of energy levels | + | A/ Complentaries of shapes, of charges, of energy levels (Program writing / reading) |
| − | B/ Thermodynamic and kinetic of the interaction (reversibility, lability), covalent / non-covalent bonds | + | B/ Thermodynamic and kinetic of the interaction (reversibility, lability), covalent / non-covalent bonds, short-range/long-range |
C/ Interactions of molecules with their environments (possibly in flux of energies far from equilibrium) | C/ Interactions of molecules with their environments (possibly in flux of energies far from equilibrium) | ||
I: Integration | I: Integration | ||
| + | A/ Collective structuring | ||
| + | B/ In space: From sub-nano, to meso, to macro | ||
| + | C/ In time: Modulation of structures, oscillations | ||
| + | D/ Emergence of new properties because of the network topologies (feedback loops) | ||
| + | E/ Emergence of new functions | ||
| + | |||
| + | |||
| + | Characteristics for supramolecular complexity | ||
| + | Specificity of interactions and integrations | ||
| + | A/ From bimolecular recognition (host-guest) to large self-assemblies | ||
| + | B/ Hierarchy of self-assemblies | ||
| − | + | Dynamics is important and can take place at the three levels M, I, and I. | |
In time and space | In time and space | ||
| − | A/ | + | A/ Conformational Dynamic |
B/ Constitutional dynamic: reversibility of the structure of the systems components | B/ Constitutional dynamic: reversibility of the structure of the systems components | ||
C/ Network dynamics in coupled reactions | C/ Network dynamics in coupled reactions | ||
| + | D/ Reversible dynamics at the three levels allow adaptation | ||
| + | |||
| + | Reversibility is an important requirement for evolvability | ||
| + | A/ Creates stocastic behavior for exploration of phenotypes | ||
| + | B/ Generate adaptativity by "mutations" which are driven by internal, or environmental parameters (e.g. stimuli, effectors) | ||
| + | |||
| + | Cooperativity is part of the integration processes which is important for modulations | ||
| + | A/ Allosteric effects | ||
| + | B/ Long range interactions | ||
| + | |||
Bottom-up approach for structuring of hierarchical supramolecular architectures | Bottom-up approach for structuring of hierarchical supramolecular architectures | ||
Version du 19 janvier 2012 à 15:01
Rédacteurs: Nicolas Giuseppone, Mario Ruben, Mihail Stadler, Franck Hoonakker, Emilie Moulin, Jean-Marc Planeix, Mourad Elhabiri, (Ali Trabolsi)
Definition of complexity
C = MxIxI
M: Multiplicity; A/ One single molecule can present several properties e.g. Multiplicity of binding sites, number of energy levels.... B/ Mutiplicity of components: number of components (molecular) /constituents (supramolecular) in the system
I: Interaction A/ Complentaries of shapes, of charges, of energy levels (Program writing / reading) B/ Thermodynamic and kinetic of the interaction (reversibility, lability), covalent / non-covalent bonds, short-range/long-range C/ Interactions of molecules with their environments (possibly in flux of energies far from equilibrium)
I: Integration A/ Collective structuring B/ In space: From sub-nano, to meso, to macro C/ In time: Modulation of structures, oscillations D/ Emergence of new properties because of the network topologies (feedback loops) E/ Emergence of new functions
Characteristics for supramolecular complexity
Specificity of interactions and integrations A/ From bimolecular recognition (host-guest) to large self-assemblies B/ Hierarchy of self-assemblies
Dynamics is important and can take place at the three levels M, I, and I. In time and space A/ Conformational Dynamic B/ Constitutional dynamic: reversibility of the structure of the systems components C/ Network dynamics in coupled reactions D/ Reversible dynamics at the three levels allow adaptation
Reversibility is an important requirement for evolvability A/ Creates stocastic behavior for exploration of phenotypes B/ Generate adaptativity by "mutations" which are driven by internal, or environmental parameters (e.g. stimuli, effectors)
Cooperativity is part of the integration processes which is important for modulations A/ Allosteric effects B/ Long range interactions
Bottom-up approach for structuring of hierarchical supramolecular architectures
Individual molecules contain a program which code for hierarchical self-assembly
Bottom-up approach for functions design A single system : 1 property A complex system : Multiple properties
Bottom-up construction of molecular networks